No way would Congress make them into a state, but with the permission of the state and federal governments they might be able to join Pennsylvania or West Virginia.
But the problem with these things is that most of the tax money comes from the suburban areas, so that taxes may actually go up for Western Marylanders if the state is broken up.
FWIW, The colonial charter defined the colony's borders before the land had been very well explored. Depending on which branch of the Potomac one considered, Maryland could have had a very different shape.
That's why they should join a larger state --WV or PA -- instead of going it alone.