I do not know much about date rape drug but my daughter is having a lot of dental work done and that is what they gave her to take an hour before her appointment. She is out of it within a few minutes. She has no memory of the appointment last week and today she was that way within a few minutes. By the time I got her to the office which is a little over 5 minutes away, I had to help her get out of the car and into the office. I had to laugh at her even though it wasn’t funny for her. So, yes, the drug does not take long to work.
I recently had a bit of medical work done and they gave me some "happy juice" (as the nurse lightly put it). I was completely functional. No memory of anything though.
Mrs WBill said that she had to chew on me during the trip home. We live maybe 10 min from the doc's office. I kept giving her the wrong directions on how to get back to our house. Finally, she said "Enough. Cork it!". I replied, "OK" and blissfully went along. :-)