More likely is that several States will begin to ignore Federal Laws leading to a Constitutional crisis. It does seem to be coming...
Actually, we have had a Constitutional crisis for the past 4 years. Our government, as it operates today, is irreparably broken and cannot be fixed at the ballot box.
So, you are correct. How the states respond to the continued ignorance and usurpation of our Constitutional rights is the key. The RINOpublican governors appear to be waiting to see who blinks first.