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Glad it works for you also. It is still hard to find many SAM-e comments on forums. Since Nature Made and others obviously sell a lot of it, I’m wondering if customers find it so trouble-free and effective that they find no reason to go on the Internet and complain about it (unlike SSRI users and their endless blogs). Maybe there are more European-language comments about SAM-e out there, but I have never taken the time to locate them.

Have you looked into any of the improved folate derivatives such as MTHF/Quatrefolic (these play into the methylation cycle as does SAM-e). There is the prescription drug Deplin and very close OTC forms like Quatrefolic. I am just starting a modest dose along with SAM-e to see how it goes. There is evidence that many people are deficient in the metabolic ability to convert regular folate into the form that will cross the blood-brain barrier; the products mentioned above are in that form already.

None of these (including SAM-e) are cheap or generally covered by insurance. Tough to afford for people who can’t work because of their afflictions but that’s just how it is. I’ve quit SAM-e probably three or four times because of costs but never experienced a discontinuation syndrome in the slightest. Still only take 400 mg where 800 to 1600 would probably be better (but even 400 works).

Back to the original thread theme, I doubt if we will ever hear about a mass murder where SAM-e is suspected of playing a role.