Huh? A calorie has always been a calorie and it will always remain such. A calorie is a measure of the amount of energy and this is exactly how it is defined. It is always the same no matter what. The metabolization of fat, carbs and amino acids will all require different pathways and the efficiencies will not be the same for all of those processes. You're confusing calorie with efficiency. Even so, a calorie is always a calorie.
I see you are still railing on fructose and continue to offer that same study on fructose and de novo lipogenesis as proof of the ill effects of fructose. I don't know why you persist, because it has been explained to you many times, and in great detail, that there is very little de novo lipogenesis going on in the human body. So much for that open mind you were critical of earlier.
Fat gain in humans is almost entirely due to dietary fats. De novo lipogenesis is rare and can only account for the most minute amount of fat gain. It could never be responsible for the incredible amount of maladies you appear eager to blame on it. You seem ready to believe that a diet high in fruit is dangerous. Call me crazy, but that's just crazy.
Of course, if you overwhelm the body with anything, including fructose, all sorts of bad things can occur. Feeding lab animals, or humans, quantities of ingredients that have no relationship to the real world is a very common practice by those looking to create alarm in the quest for grant money. And that's really what all this is. There is no way fructose consumption can be responsible for all the things charlatans like Taubes and Lustig claim. It's just plain old every day alarmism designed to separate people from their money. P.T Barnum understood human nature well.
A calorie is a calorie only in a bomb calorimeter...who knows how any calorie behaves from one individual to another. That is what we need to figure out, but I respectfully disagree about fat gain being due to dietary fat...it has far more to do with the insulin response, which fat intake alone will not stimulate. I do agree with you however, that fruit will also not make you fat...this has more to do with the amount of water in the fruit, and less to do the fructose in the fruit.
We need to stop trying to pigeon hole everyone into the same peg....we are all different, and different solutions are needed for each individuals weight gain/weight loss challenges.