There is a high potential for remarkably stupid pop culture questions. This would be a strength for Obama and Romney's Achilles heel. No matter it's utter irrelevance to presidential politics, it could make Mitt look “out of touch”. Spin fodder for Axelrod.
Romney just has to keep coming back to the economy and ask those people if they are better off today than four years ago.
Crowley is not going to allow those questions in any case because she does not want to look like an obvious idiot. She wants to preside over something serious. She approves of the questions to be asked from what I hear.