Most people don't like getting shot. The ones who are crazy or drugged enough to not care, will also need a lot of putting down.
One rule: although bigger is better, a .22 in the hand beats a .45 left home in the gun safe.
They're easy to aim, shot place, and plenty loud.
For wifey, we have a 20 gauge Mossberg scattergun - being as she's well under 90 pounds, a 12 gauge was gonna be too oppressive for her to handle.