I can do center of mass with a 45 or 9mm, but I can walk a pop can with my 22s....both ruger and walther. It’s a surprising plus up in accuracy. You wouldn’t expect it, but it’s definitely there. I have no doubt with my 22s I’d put 3 or 4 rounds in a target for every 1 with a 45.
.22’s HP’s are also a little messy to. They’ll cut up the guts if they hit a bone and splinter.