A big problem of high PSAs when no cancer is present - is that it often leads to a biopsy, where they do about 30 pokings into the prostate for samples, leaving your prostate a bloody mess of holes. It will heal, but there are ramifications of that where the healing process takes time, an in the meantime you are uncomfortable, and experience unsettling bleeds.
>> A big problem of high PSAs when no cancer is present - is that it often leads to a biopsy <<
But often not. In my case, a high PSA reading led to a six-week course of antibiotics, which zapped a prostate infection and brought the PSA back down.