There are special tools made just for removing the spines (large & small) without getting them in you:
This set includes an acrylic cutting board, and the tool at the left is made for holding the pads down while using the middle tool for "de-stickering" them. I'd think that some good tongs and a sharp regular knife for harvesting pads would be a good addition to the toolkit.
The above tools are pictured (and available) onlline at http://www.gourmetsleuth.com/Articles/Ethnic-Unique-Foods-Ingredients-645/nopalitos.aspx.
Fortunately, my brother-in-law has a special cultivated spineless variety growing on his place in central Texas, and has offered me cuttings...
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I like most green vegetables, but, I've never eaten nopalitos -- so I don't know if they are worth the trouble...
I’ve had them, they’re good but would be bland if served by themselves. We added them to eggs, tomatoes, & onions to make a burrito filling. You cut them into squares and boil them to remove the slimy texture. Nopalito is supposed to have some benefit for diabetics.