I recommend not giving burglar’s or robbers a chance to shoot first. Further I recommend number 1 shot, as it will penetrate to the back of a man, where the spinal chord is likely to reside, and you have more chances to hit it than you would with 00 shot.
Just make sure the thief you have in your sights is not one of our esteemed GOP Senators (reaching across the aisle) or about half the GOP House. In that case you are unlikely to hit any spine.
Did you ever see what #1 shot does to a bowl of jello?