Laws are meant to be enforced, they aren't suggestions.
When the States formed the Union, they agreed to abide by the conditions that were stated in the Constitution, which was meant to be stronger then the Conferation.
I know that secession is not granted in the Constitution and wasn't even stated to be allowed in the Confederate constitution, no government could survive if any State could just leave for any reason.
Washington upheld federal laws with force.
Jackson was planning to.
Lincoln was forced to.
The only people who had a real complaint about their rights being violated were the millions of slaves that the South was willing to die trying to keep in slavery.