Yes it can, if it is nuclear. What is the risk? It's not like Russia, China, France, England or India will nuke Tel Aviv in retaliation. Pakistan? Maybe, but they couldn't deliver the weapon.
There is a risk that China and Russia will enter into the mix. You can risk a wider war. This attack by Israel needs to be carefully calulated because there is no margin for error.
http://atimes.com/atimes/middle_east/ml13ak01.html
I suggest you see the movie “Threads”. It is available online. Its about how a conflict in Iran turns into a full blown nuclear conflict.