In a hell year for Republicans, in a state that was moving blue, to a Dem who was the son of a mega-popular governor and lied about his stance on abortion.
None are applicable to dealing with Obama.
It is entirely disengenuous for a Romney supporter to mention SENATOR Santorum losing a Senate race.
Sen. Santorum WON two Senate races and was in the Senate for 12 years. He won multiple terms to the House prior to that. He won in a very blue state, Pennsylvania that is also a democratic stronghold.
Romney, on the other hand, ran for the Senate and was resoundingly defeated even in an up year for Republicans in Massachusetts. In fact, it was the same year that Sen Santorum WON his first race for the Senate.