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To: neverdem

I went to the site and searched. I saw an article that said a study done in Bangladesh came up with NO LINK BETWEEN ARSENIC AND DIABETES. Just say’in.


93 posted on 12/28/2011 8:50:22 AM PST by SnarlinCubBear (Sarcasma - Comforting relief from the use of irony, mocking and conveying contempt)
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To: SnarlinCubBear; 1010RD
I went to the site and searched. I saw an article that said a study done in Bangladesh came up with NO LINK BETWEEN ARSENIC AND DIABETES.

Here's the first paragraph of the discussion section of the citation linked in comment# 87:

The arsenicosis-endemic areas of Zimapán and Lagunera were chosen for this study because tens of thousands of local residents are currently exposed to a wide range of iAs concentrations in drinking water and because relatively detailed information exists about historical levels of iAs in the local drinking water supplies. Unlike most previous studies, we used multiple biomarkers to classify diabetes and to characterize exposure to iAs. In spite of a relatively small number of subjects recruited for this study we were able to show that the exposure to iAs was positively associated with all three diabetes indicators. Our findings contradict results of a recent study that found no significant association of iAs exposure with diabetes in another arsenicosis area located in Bangladesh [30]. This study used only glycated hemoglobin (HbA1c) and glucosuria to classify diabetic individuals. Although the HbA1c level in blood is now an accepted measure for diagnosis of diabetes in the US, it is unclear whether it was also validated for the Bangladeshi population. Glucosuria is not a reliable indicator of diabetes [31]. Thus, using the validated diabetes indicators may be essential for linking iAs exposure to risk of diabetes. Notably, our data on the negative associations between iAs exposure and FPI and HOMA-IR suggest that the mechanisms of iAs-induced diabetes differ from those underlying type-2 diabetes, which is typically characterized by insulin resistance (i.e., increased HOMA-IR) and hyperinsulinemia [32].

They have problems with the methods in the Bangladeshi study. I can't help with all the abbreviations used, but a "List of Abbreviations" immediately follows the one paragraph of "Conclusions" which follows the discussion section. If you read all of the discussion sction, you'll find some esoteric abbreviations, e.g. HG-CT-AAS. Translated that means hydride generation, cryotrapping atomic absorption spectrometry, a fancy technique to detect and quantify elements, in this case inorganic arsenic and its metabolites in urine.
94 posted on 12/28/2011 1:48:12 PM PST by neverdem (Xin loi minh oi)
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