Where he goes off into neverneverland of “sentient” cells explains why he publishes apparently only in his own vanity press.
Selection gets rid of the “deadwood” of unfavorable variations.
Expression of error prone DNA polymerase creates variations, both favorable and unfavorable ones.
Innovation, the “novelty in evolution” we are discussing is not an accidental process - but the error prone DNA polymerase DOES introduce random changes (mutations) in the genome. The changes it introduces are NOT directed by a sentient cell.
Error prone DNA polymerase does not work only on pseudogenes - it works in introducing mutations throughout the entire genome.
Moreover bacterial genomes are very compact and contain very little noncoding DNA - including pseudogenes.
It is hardly mechanistically capable of being a “tote bag” of discarded mutations for every gene in the genome that may have a function in different environmental conditions when there are so very few pseudogenes and so many actual genes.
Sorry, it is the actual genes that are modified through error prone DNA polymerase - and those modifications are variations subject to natural selection.
Still struggling under the mistaken impression that all cell stresses lead to cell death?
How humble of you.
Where he goes off into neverneverland of “sentient” cells explains why he publishes apparently only in his own vanity press.
True to form you use Ad Hominem. Look, I'm sure you are a Harvard grad, have a PHD in genetics and wrote a book or two, but to say that the following publications are vanity press is a stretch
Shapiro JA. 2005. Retrotransposons and regulatory suites. BioEssays 27, 122-125.
Shapiro JA. 2005. Thinking about evolution in terms of cellular computing. Natural Computing, 4, 297-324.
Shapiro JA. 2006. Genome informatics: The role of DNA in cellular computations. Biological Theory 1(3): 288-301.
Shapiro JA. 2007. Bacteria are small but not stupid: cognition, natural genetic engineering and sociobacteriology. Studies in History and Philosophy of Biological and Biomedical Sciences 38 (2007) 807–819.
Shapiro JA. 2009. Letting E. coli teach me about genome engineering, Genetics 183: 1205–1214
Shapiro JA. 2009. Revisiting the central dogma in the 21st Century. Ann NY Acad Sci 1178: 6-28. Paper presented at a symposium on Natural Genetic Engineering – Natural Genome Editing, July 2-6, 2008, organized by Guenther Witzany.
Shapiro JA. 2010. Mobile DNA and evolution in the 21st Century. Mobile DNA, 1:4.