The 14th Amendment says the states can't violate those rights. It has nothing to do with the Commerce Clause.
The drug issue is especially thorny. What if a state or municipality decides to legalize the sale or possession of drugs? Where do you draw the line between state and federal authority in such matters?
I have no idea why you should find drugs a 'thorny' issue with respect to the Commerce Clause and Tenth Amendment.
What is so hard about honoring the original Constitution in the matter?
Thanks.