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FDA Limits Highest Dose of Zocor
http://www.webmd.com/cholesterol-management/news/20110608/fda-zocor-simvastatin-dose-limit?ecd=wnl_nal_chl_060811 ^

Posted on 06/11/2011 4:34:55 PM PDT by chessplayer

No New Patients Should Get Highest Dose Due to Muscle Injury Risk

(Excerpt) Read more at webmd.com ...


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1 posted on 06/11/2011 4:34:58 PM PDT by chessplayer
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To: chessplayer

Shouldn’t they know these things BEFORE it is prescribed?


2 posted on 06/11/2011 4:40:58 PM PDT by ilovesarah2012
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To: chessplayer

Cholesterol drug. Am I the only person who has never had a cholesterol problem? Any time I have it checked my doctor tells me it’s perfect and to keep doing whatever I’m doing, which is, to eat anything I want, in whatever quantities I want, anytime I want. I am 65 years old.

Genetically lucky?


3 posted on 06/11/2011 4:43:32 PM PDT by Graybeard58 (Free at last, free at last, thank God almighty, I'm free at last (retired Dec 1999))
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To: Graybeard58

I told the doc I would never take a statin, started having oatmeal for b’fast and milk instead of half and half in my coffee, and my cholesterol dropped into normal.

No half and half is hard for a Norwegian, but sacrifice is part of life, I suppose.


4 posted on 06/11/2011 4:48:04 PM PDT by bboop (Stealth Tutor)
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To: ilovesarah2012
“Shouldn’t they know these things BEFORE it is prescribed?”

Unfortunately, a lot of information doesn't come out until post-marketing. Clinical trials, even with thousands of patients, can't tell you everything that could be clinically significant.

Not long ago the outcomes analysis, statistical research people (who produce data of the type that the uninformed in government have shaped their ridiculous health care policy on) were pushing for everyone who had a myocardial infarction (heart attack) to be put on the maximum dose of Zocor (or an equivalent medication) prior to discharge from the hospital - as a policy edict. A lot of those patients went on to have side effects, but might not have if they had been started on a lower dose and then titrated.

5 posted on 06/11/2011 4:49:30 PM PDT by pieceofthepuzzle
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To: bboop
“No half and half is hard for a Norwegian..”

Maybe you could come up with a great ‘heart healthy’ lutefisk diet, and become rich!

6 posted on 06/11/2011 4:52:05 PM PDT by pieceofthepuzzle
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To: bboop

I told my doctor the same, but after a year of oatmeal and soluble fiber additives to everything I drank and exercising every day, my cholesterol had not budged. A month on 40mg simvastatin daily and it dropped by 100 points. Diet changes don’t work for everyone.


7 posted on 06/11/2011 4:52:30 PM PDT by Kellis91789 (There's a reason the mascot of the Democratic Party is a jackass.)
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To: bboop

I drink H&H almost every day. My only complaint is that it costs twice as much as milk..... but still worth every penny.


8 posted on 06/11/2011 4:57:08 PM PDT by Graybeard58 (Free at last, free at last, thank God almighty, I'm free at last (retired Dec 1999))
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To: Kellis91789
I have always had a low cholesterol problem ~ and I say problem because for many years "they" always came back to me and asked if I'd like to donate more blood for study.

After a couple of hits at that bong I quit cold turkey and did without tests for a couple of decades.

Over that time my cholesterol levels declined.

I've known about this "statin intramuscular pain" problem for a number of years.

It's very real. My doctor prescribed it for some reason and I told her I would start out real low, and even with 1/4 of a 10 mg pill I had pain in my hands and arms. Cutting that back to 1/8 of a pill I had pain in my hands alone but it lasts for about 2 weeks.

The problem is many of us (20%) do not produce the enzyme that metabolizes statins to remove them from our bloodstreams, so what we end up with is an OVERDOSE.

This article, or one just like it, starts with a discussion of an 80 mg pill!

OH MY GAWD!!!!!!!!!!!!!!!!!!!

9 posted on 06/11/2011 5:09:50 PM PDT by muawiyah
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To: Graybeard58
Genetically lucky?

Very.

10 posted on 06/11/2011 5:50:42 PM PDT by null and void (We are now in day 870 of our national holiday from reality. - Obama really isn't one of us)
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To: muawiyah
The problem is many of us (20%) do not produce the enzyme that metabolizes statins to remove them from our bloodstreams, so what we end up with is an OVERDOSE.

AHA! I had muscle aches with every statin on the market.

Now taking 2000 mg of niacin every day, and Dr is pleased with my cholesterol, and I don't feel like I'm ninety...

11 posted on 06/11/2011 5:55:49 PM PDT by null and void (We are now in day 870 of our national holiday from reality. - Obama really isn't one of us)
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To: muawiyah

Yes, I know that I started to have muscle pains in my sides and shoulders after beginning on simvastatin. I was taking aspirin for it. A month ago I learned that statins reduce the body’s natural production of Co Enzyme Q10 as well as the LDL, so now I take 100mg of CoQ10 everyday and I don’t the muscle pains anymore. Studies on CoQ10 countering the muscle pains seem to be inconclusive, but it works for.


12 posted on 06/11/2011 6:04:18 PM PDT by Kellis91789 (There's a reason the mascot of the Democratic Party is a jackass.)
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To: null and void
Doing some research on this statin pain problem I discovered that back in the early days of research into ways to stop or relieve AIDS researchers got into injecting massive doses of every sort of drug into selected AIDS test subjects just to see what happened.

Well, you can imagine what happened to 20% of them who got statin injections!!!!!

They figured that one out real quick, but no one has made a general warning on the matter.

BTW, statins did nothing to relieve AIDS.

13 posted on 06/11/2011 6:06:03 PM PDT by muawiyah
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To: Kellis91789

BTW, I really can’t relate to a 100 point drop. Inconceivable in fact. How do you guys walk around with that much fat in your systems.


14 posted on 06/11/2011 6:07:52 PM PDT by muawiyah
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To: null and void; Graybeard58
Rad the literature on low cholesterol very carefully. We may have one of several different diseases!

The high cholesterol tribe considers low cholesterol to be a sort of illness!

15 posted on 06/11/2011 6:10:09 PM PDT by muawiyah
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To: Kellis91789

You’re right. Statins deplete your levels of Coenzyme Q10. They create a strain on your liver and raise liver enzymes. Whoever is on statins needs to have their liver enzymes checked at least every three months.


16 posted on 06/11/2011 6:14:25 PM PDT by toothfairy86
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To: chessplayer

Statin drugs are a scam.

There is no correlation between lower cholesterol and lower incidents of cardiovascular death. HMB-CoA reductase inhibitors produce rhabdomyolysis.

Since the advent of statin drugs the number of deaths due to heart attack and stroke have not decreased.

Example:

“Two widely prescribed cholesterol-lowering drugs, Vytorin and Zetia, may not work and should be used only as a last resort, The New England Journal of Medicine said in an editorial published on Sunday.

The journal’s conclusion came as doctors at a major cardiology conference in Chicago saw for the first time the full results of a two-year clinical trial that showed that the drugs failed to slow, and might have even sped up, the growth of fatty plaques in the arteries.”


17 posted on 06/11/2011 6:19:14 PM PDT by WaterBoard
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To: Graybeard58

About a year ago, my LDL was a little over 100 and my HDL was 58. Since I am in the very highest risk category for heart disease, my doctor immediately prescribed Zocor for me. I refused to take it and wanted to try to lower my LDL on my own. I watched what I ate, exercised more, and ate about a cup of oat bran every day. (half a cup before morning meal, half a cup before evening meal) Oat bran is even more effective than oatmeal at lowering LDL. The higher the LDL the better oat bran works. Went in for a checkup 6 months ago and my LDL was 85, HDL was 89, and triglycerides were 29. But now the numbers are getting worse again. My latest checkup yesterday my LDL has risen to 100 and my HDL has dropped to 75. My nurse was amazed at the numbers considering I was`nt taking any cholesterol drugs. I was disappointed, though because my LDL is going up again and my HDL is dropping like a rock. Considering the risk factors I have, my LDL is supposed to be under 70.


18 posted on 06/11/2011 6:35:55 PM PDT by chessplayer
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To: Graybeard58

Bodies are so different, aren’t they? I visited my great-aunt when she was 98. She still lived alone, got around in a walker. Her son lived nearby and she had someone dropping in on her to help, shop, etc. I offered to clean her frig, and when I looked in, it was all Sarah Lee and 31 Flavors ice cream and Sees Candy, top to bottom. I suggested that she needed fruits and vegetables. She said, “I have eaten like this all my life.”

She was not slim, kind of square-ish but definitely not fat. I bet her cholesterol was normal, too.


19 posted on 06/11/2011 6:42:54 PM PDT by bboop (Stealth Tutor)
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To: chessplayer

a small percentage of folks getting zocor get sore muscles and some even end up with inflamed muscles.

we usually use lower doses (20 to 40 mgs) in our patients, but still sometimes we pick up someone who gets achy on it. I never prescribed 80 mgs, but some cardiologists do use it for people with very high cholesterol and heart problems.

My mom had to stop it because of the achy muscles...she thought it was arthritis so didn’t bother to mention it to the doc, but complained to me...we stopped it and she stopped aching.

Once in a great while, you also see liver problems.

Every medicine is a “cost benefit” ratio...if you don’t get the muscle (or liver) problems with Zocor, and have heart disease, it’s worth it.


20 posted on 06/11/2011 6:57:43 PM PDT by LadyDoc (liberals only love politically correct poor people)
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