While this is undoubtedly true, the interrogator simply needs to make it understood that if the prisoner's information cannot be empirically verified, the pain/discomfort will continue or intensify until it can be.
Problem solved.
Exactly. Opponents say "the subject will say anything to avoid torture". "Anything" includes the truth.
Never ask questions whose answers cannot be verified, and let the subject know that bad things will happen if he lies to us.