Sure a wolf.
The wolf is a pack animal. When they hunt in a pack they are much more aggressive. Here is a good article for you.
Wolves are pack animals, period.
A .22? LOLOLOLOLOL
You may take out one wolf but the elation of seeing one the ground will be soon be met with you seeing nothing but eyes and teeth, while you scream “Ahhhhhhh, God!!!!!!!11”
Lone Wolf McQuade runs with nobody and it would all be over before you figured out the person in front of you is Saint Peter.