My reaction is to concede the state.
In my calculus, the hypothetical GOP senator would approve of those federal actions. "Have to vote like a DEM to get a seat from that state." Screw that, let the DEMs sink the ship. And if the GOP can't block legislation with 41 firm NO votes in the Senate, something more serious is amiss, and the eventual "reset" will be more complicated.
As it is, either the federal government shrinks, or the constitution dies.
The last vote I regretted was McCain/Palin - and I gave that one out of respect for Palin. I blank vote Snowe/Collins. I won't vote for an elitist bitch or prick, no way, no how.