“In 24 of 923 people with conditions such as Crohn’s disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, the gene was present in a variant form.”
That’s not very compelling evidence!
That’s not very compelling evidence!
"'I think this is an absolutely seminal paper,' says Judy Cho, an immunogeneticist at Yale University in New Haven, Connecticut. The strength of it, she adds, is that it proposes a very specific hypothesis — namely, the role of the sialic acid pathway in autoimmune disease — that can now be tested."
IMHO, there are relatively very few diseases where the genetic defect is limited to a single gene.
A Decade Later, Genetic Map Yields Few New Cures
Let's see how the sialic acid pathway hypothesis pans out. It could be the needle in the haystack. Maybe not. If it does, I'll bet money that multiple genes are involved in that pathway.