Yea it would. The important targets are in northern Iran. They'd be better off overflying Turkey, if the Turks would allow it.
Besides no F-22 in the region, the Israel’s are not flying stock F-16s right off the factory floor. IAI installs their own radar packages and adds much of their own weapons systems. We may know what they have, but in a situation like this it all comes down to the pilot. Sadly, there would be attrition on both sides.