Prepared or not, short of a constitutional recourse, they have no LEGAL recourse. They can rebel. Or they can call a convention. Actually, they ought to call a convention. That would be the “proper” thing to do. Rebellion, technically, should be a last resort, and unless you’ve called a Constitutional Convention, you have not exhausted your legal options.
Perhaps "rebellion lite": just ignore them and don't participate. See how bad the feds want to make an issue of it and what they're willing to do to enforce it.