I found the Glock 19 fun to shoot, but the Walther P99 fit my hand much better. I have small hands, and the thickness of the grip on the Glocks never quite fit my hand. My impressions of both were they were very reliable.
The one that stays beside me for home defense and CC though is the H&K P7M8. It is heavy, which is really noticeable while carrying, but I have 100% faith in its design and safety and I have never had a problem with it since I bought it. It's more of a radical departure from typical semi-automatics though. I mention it since I don't recall seeing it up-thread.
Bottom line, get something that fits and that you feel comfortable with. By fit I don't just mean it feels good in the hand and you can reach the trigger. You should also make sure that you can reach and use all controls, if any. Practice, practice, practice. I used to have a Walther PPK/S which fit my hand really well but would bite me on the webbing of my hand (between thumb and index finger) whenever the action would cycle. That wasn't fun to shoot.
If you have a local range where you can rent pistols to try, I would recommend that. Even better if you have a friend with a few pistols or a local club which has introduction nights.
Keep an open mind. There are many variations of semi-automatics, revolvers, shotguns out there. While the basics are the same, many of their control levers and functional components are placed differently. It may be a revolver fits your needs better, it could be a shotgun. Best to take the time to find the one that fits well.
My P-99 is the most ergonomic handgun.