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“That includes major changes in the number of chromosomes in many cases, and I have yet to be informed of any changes in the number of chromosomes which has not had a deleterious effect on the individual in which it occurs.” metmom

I have attempted to inform you about what a ludicrous and ignorant statement that is NUMEROUS times. But when ignorance is all you have I guess you fight hard to keep it.

Plants change chromosome number all the time. Many animals have spontaneous splits or joining of chromosomes with absolutely no abnormalities (i.e. a different chromosome number, but the same genes and gene copy number).

What causes chromosomal abnormalities is having ONE copy of a gene when you need two, or THREE copies of a gene when you need two. If the genes are packaged in 23 or 24 chromosomes (haploid) makes no difference.

But no doubt you will trot out your “I have never heard” ignorance again, and again and again. Don't let actual factual data get in the way of your impenetrable ignorance.