I provided the link to a PAGE. On that page was the answer I provided to you. In case you were too stupid to figure it out, I also included the actual answer I provided to you back in 2008.
For the thinking impaired I NOW provide a link, not just to the relevant page, but your question and my answer. In case you are again not smart enough to figure out how to follow that, I will also cut and paste my answer TO YOU again.
Yet somehow I suspect that you will NOT learn anything from it, and in a few months again you will be saying ‘I don't see how, nobody has explained to me, why wouldn’t a change in chromosome number be detrimental?’.
http://freerepublic.com/focus/chat/2108022/replies?c=725
To: metmom
Chromosomal fusion would not lead to aneuploidy problems.
Aneuploidy like Downs syndrome, Klinefelters, etc are either a loss of an entire chromosome or the gain of an extra copy of a chromosome.
Chromosomal fusion is just a rearrangement of the same genes in 23 packages (x2) rather than 24 packages (x2).
No muss no fuss.
There are even the relics of an unused centromere on Chromosome two and telomeres where the fused chromosomes used to end.
Just a bit of research would answer your questions.
727 posted on 10/20/2008 7:08:13 PM PDT by allmendream
Allmendream gets like this when he’s feeling threatened or insecure. Tell me, what is he being forced to eat his words over this time?
"Just a bit of research would answer your questions."
I believe that a bit of research on your part would reveal that the sequences interpreted as centromere and telomere 'relics' on Chromosome 2 occur in other places in the genome but are not considered to be 'fusions' there.
I believe a further bit of research on your part would reveal that comparing the genes on the chromosomes in question do not line up as expected if there were a fusion.
So, not only are you forced to cherry-pick the data wrt 'fusions' you are also forced to assume the genes have moved around 'post-fusion'.
Just if you're interested in research...