The New Madrid Fault appears to be extremely old from the studies I’ve seen. Not saying there won’t be another quake but the area doesn’t seem active like the various zones in California.
a little more info
"The greatest earthquake risk east of the Rocky Mountains is along the New Madrid fault system. Damaging earthquakes are much less frequent than in California, but when they do occur, the damage can be far greater, due to the underlying geology.The New Madrid fault system, or the New Madrid seismic zone, is a series of faults beneath the continental crust in a weak spot known as the Reelfoot Rift. It cannot be seen on the surface. The fault system extends 150 miles southward from Cairo, Illinois through New Madrid and Caruthersville, Missouri, down through Blytheville, Arkansas to Marked Tree, Arkansas. It dips into Kentucky near Fulton and into Tennessee near Reelfoot Lake, and extends southeast to Dyersburg, Tennessee. It crosses five state lines, and crosses the Mississippi River in at least three places."