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Mast cell activation disorder/syndrome (MCAD/MCAS)
A disorder or syndrome in which there is evidence of the systemic, inappropriate release of mast cell mediators. While people with MCAD/MCAS have a normal or near-normal tryptase level and a bone marrow biopsy that contains a normal number of mast cells, they experience most of the same symptoms as does someone with mastocytosis.

I have been suffering with a MCAD for 1 1/2 years now. They still do not know the cause of it.
I take several meds a day to help keep the massive hives down. (it works about 80% of the time)
I also suffer from moderate to severe angioedema.
Meds I take daily...
300mg of Rantitine (Zantac)
5 to 10mg of Xyzal
and 10mg of Singulair
I also keep a Epi-Pen with me at all times. (you should also - ask your Dr to prescribe it for you, also keep some liquid Benadryl around). Also stay away from foods that are high in histamine (Google Foods High in Histamine), chances are your histamine levels are already high and staying away from foods that are high in histamine will help keep your histamine levels down as much as possible. It's not that you are allergic to foods high in histamine only that they increase the high levels of histamine already in your body. I have had both the RAST and Scratch tests done for 72+ allergens and I am not allergic to any of them, again they don't know yet what caused my MCAD yet. They may never know. I will wait another 6 months and if it does not burn out like they say it may do then I will be heading to TN to get tested here http://www.tmsforacure.org

The above meds are the ones that work the best for me at this point - but I have been on several types of antihistamine's and several combos of antihistamine's. I had to wean myself off of Prednisone.