[Jean S]

If his popularity tanks, she’ll run against him in 2012. Wont that be amusing!

Oh yes! And it's very plausible.

[Sir Clancelot]

And when Hillary runs in 2012, she has senatorial experience and foreign policy experience. She’ll be too old to run in 2016, so I think it’s more likely than not that she’ll resign in about a year or so to prepare to run.