Commentary
Japan H1N1Tamiflu Resistance Levels Raise Concerns
Recombinomics Commentary 12:19
December 20, 2009
http://www.recombinomics.com/News/12200902/H274Y_Japan_Level.html
Aichi Prefecture, Nagoya-year-old man who died in the pandemic influenza infection (49), the new virus announced it had confirmed the effectiveness of Tamiflu drug resistant. Tamiflu-resistant virus was confirmed in 26 of cases nationwide, in the prefecture of four cases. People were confirmed dead from the first time.
The above translation refers to 26 cases of H274Y in Japan, including 4 cases in Aichi. These high numbers may have contributed to the recent totals posted by WHO, which were approaching 100. Although the WHO report indicated that this spike in cases was in the past few weeks, the locations were not given. However, the CDC weekly reports have cited 30 cases in the past 5 weeks and the Netherlands has increased its total to 13. However, Vietnam reported a cluster of 7 cases in the New England Journal of Medicine, which were from infections in July, but were not confirmed until September and were first made public in the NEJM paper. Some reports from Vietnam suggest 6% of H1N1 cases had treatment failures consistent with H274Y, but the number of lab confirmed cases remains unclear.
Similarly, NIID in Japan deposited 68 full sequences which included eight with H274Y, but it was unclear how representative the numbers or frequencies were. Other sequences from Nagasaki Prefecture were of the same sub-clade that had 3 isolates with H274Y, suggesting the Nagasaki sequences had H274Y, but only HA sequences had been released.
Thus, the above translation confirms that the number of cases in Japan is high, and phylogenetic analysis of the recently released sequences suggests significant silent spread, increasing concerns that H274Y will soon be fixed in pandemic H1N1.
S-2 Flu
Joined: 03 Dec 2006
Posts: 1682
Location: Alabama
Posted: Sun Dec 20, 2009 8:45 am Post subject: Daily Fatality Summary
DAILY FATALITY SUMMARY(Reports posted on December 19,2009)
UNITED STATES—0
CANADA—0
WORLDWIDE—39
China(Hong Kong) 1
Costa Rica 6*
Egypt 23*
India 8
Pakistan 1
NOTES:The US figures are unchanged.
The increase in Costa Rica is the first in nearly a month; there have been 47 deaths. Egypt`s toll has doubled in a week to a current figure of 84.Turkey is ominously quiet.
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