[JOAT]

Now why is it that the p53 gene is mutated in about 50% of cancers?

So WHY is it mutating?

Mutations are caused by something, they don't just "happen."

You act as though the mutation is the cause, not the result of some external force.

[allmendream]

Why is it mutating?

Because mutation happens all the time as a result of cross linking radiation, intercalating agents, and even just the process of DNA replication.

Mutations introduced by DNA replication is one of the contributing factors to cancer.

Thus we see that cell lines that are under constant replication are MUCH more prone to cancer than cells that rarely if ever replicate.

There is a reason prostate cancer is common and brain cancer or heart cancer are rare.

Do you want me to answer my own question?

I will if you want, as it seems unlikely that you or Mr. “I am smarter than a doctor” has any idea why the p53 gene is mutated in about 50% of cancers.