Not really. We won a war against those who wanted to do so, so they could maintain their slave based economy. And that was an issue that had been festering since the Constitution was written. We won the war and wrote into law that slavery was illegal. I don't recall any amendments on secession.
As said earlier in this thread, the Constitution is silent on the matter. The Declaration however, spelled out quite clearly that there are valid reasons for doing so, and when those long trains of abuse finally get too much, then not only is it a people's right, it's their duty.
Having done just that, how could the Founders deny the possibility to future generations if their little "experiment" in human government failed.
To be sure, it should not be undertaken for light and transient causes, and the Founders did give us plenty of tools for redress of grievances. Secession would be the final tool for the final straw.
Such as periodic elections. Voting the bums out is a whole lot better than wrecking the Union.