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The RNC can choose whom to support as a candidate with contributions, training, etc. (and in my experience they generally ignore conservatives unless that candidate can raise several hundred thousand dollars unaided).

However, there was a case here in WV in 2004 where someone not known politically was encouraged under the "outreach" program to file for the office of State Senator, but it was then found after the deadline for filing that he was serving time in prison. The state party begged and pleaded with him to withdraw his name before the end of the period for withdrawing candidacy (so that the state party could have filled the vacancy on the ballot). But he refused and since the party is powerless to cast people out of the party or even deprive them of their candidacy, we were stuck with all the negative publicity that year of "the GOP" running a felon for high office.

And of course since the Democrats have total control of the election process, we can;t even get bills passed to rectify that possibility.