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Yes, Brit is a unique figure who is not replaceable. I've read speculation that they might return with more than one host. Perhaps with an expanded "panel" segment, which would serve to take pressure on the host.
Megan Kelly comes across as a smart, tough lawyer, but does she have the journalistic chops? Bret Baier has been the Friday host of Special Report, but to me he seems like a kid compared to Brit Hume. Maybe Megan and Bret could make a good tag team.
Jim Angle was always a good replacement.