Look Santorum won in 2000 despite almost every other GOP Senator from 1994 losing. Dems picked up a ton of Senate seats in that election.
If we constantly say things like "Oh Bayh can't be defeated, why bother" we score our own goal.
Look 2010 will be an opportunity like 1994 to take on these incumb Dems who seem unassailable.
We need to target EVERY race. Just like the Dems do.