It has been a temporary setback. Destroyed her? Heck, they just opened wide the door for her. An Obama presidency, if there isn't a super-majority in Congress, is going to have problems from the get-go.
Look ahead.
I look to the mid-term elections now. Will stock up on light-bulbs and other necessities like my depression mentality relatives did and will hold on for the ride. If Zero and a dem congress do what Clinton and the 1993 congress did, or what Hoover did, there will be a tidal wave back to conservatism. We just have to be sure that people know that it's an option.
His own inexperience.
The entrenched system on the hill.
Porkbarrel including Military contracts.
AND the biggie - A crap Economy. That will tie his hands for sometime.