Here’s another quote from the SAME article. Are you starting to catch on yet?
“The abundance of naturally occurring genetic variation that is affected by Hsp90 was remarkable. The authors also genetically mapped the traits that could be affected by HSP90 and found that nearly every complex trait in A. thaliana that they investigated could be affected by HSP90-dependent genetic variation.”
Hsp90 is not a DNA methylating enzyme, it is a chaperon that is involved in folding the amino acid sequence of a protein into the proper 3-D configuration so that its electromagnetic properties can act in a specific manner.
This is one of the last steps in performing biological function, about as far as from where epigenetic factors act as is possible to get.
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To review.......
Information is in DNA. This information is subject to change through mutation. This information specifies the amino acid sequence of a specific protein that performs specific structural/enzymatic/signaling/etc function(s).
This information is accessed when RNA polymerase binds to non-histone bound (unmethylated) DNA that is bound by transcription factors (such as heat shock proteins for proteins that might be handy during heat) and makes a mRNA transcript of the information. THIS is where epigenetic works, in the passing down of or development of a particular methylation pattern to DNA, thus turning some genes off.
mRNA is spliced such that it is read in the best manner with many ‘nonsense’ sections being taken out, or to specify an entirely different configuration as circumstances dictate.
The spliced mRNA goes to a ribosome where the information is translated into the amino acid sequence of a protein by matching it up with its corresponding tRNA that carries a specific amino acid.
Amino acid sequence of a protein folded into proper 3-D structure by chaperon proteins like Hsp90.
Protein performs specific function.