desperation Look up desperation at Dictionary.com
c.1366, from L. desperationem, noun of action from desperare “lose hope” (see despair). Desperate (adj.) is attested from 1483, of persons, “despairing, hopeless,” from L. desperatus “given up,” pp. of desperare. In ref. to conditions, recorded from 1555; of an undertaking, from 1642.
despicable Look up despicable at Dictionary.com
Failure to remain in faith in Christ by leaving the Hope He provides.
Great tagline!
despair: to be without hope.
http://dictionary.reference.com/browse/despair
There are variations, of course, and its original meaning refers to a loss of hope in God and His mercy.