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The elder George Bush had this condition arise while president and didn’t resign. Shep, you ignorant twit!

While jogging at Camp David on a Saturday afternoon (May 4, 1991), Bush developed shortness of breath, chest tightness, and a general feeling of fatigue. A White House physician discovered Bush had a rapid irregular heartbeat, ultimately diagnosed as atrial fibrillation due to hyperthyroidism (see below). [9] [More]
Bush was transferred to Bethesda Naval Hospital by helicopter. His ventricular rate was 150/min [3e]. Cardiologist Dr. Allen M. Ross prescribed digitalis, procainamide, and Coumadin [9]. (Note: Digitalis slows the heart, procainamide can change the rhythm pattern from atrial fibrillation back to normal, and Coumadin prevents blood clots, one of the main complications of atrial fibrillation.) Abrams writes:

According to the doctors’ plan, if the drugs failed to affect the arrhythmia — as initially they did — an electrical shock would be administered the following day, a common way of returning a patient’s rhythm to normal. When it was announced that Dan Quayle would be acting president under the Twenty-fifth Amendment provisions while Bush was under anesthesia for the cardioversion — if it was required — a different kind of shock reverberated across the nation. The prospect of Quayle as president brought home sharply the electorate’s lack of confidence in his ability to lead. [1a]
The drugs were effective. By 10:25 pm on May 5, Bush’s heart rhythm was normal. About 5 am the following morning, however, atrial fibrillation recurred. It was decided (by whom?) to continue the drugs rather than use electrical cardioversion. Bush returned to the White House later that day. [1a]. Comment: It would be useful to have information on how long Bush used these medications. Both digitalis and procainamide can affect higher mental function.