It would. Your example demonstrates that the second amendment does not apply to the states -- if it did, equal protection and due process would demand that the laws be uniform.
"Since they are not limited in what they may regulate (your notion) why haven't the folks at Commerce cracked-down on the lack of 'uniformity' in this regard?"
Well, the Commerce Clause gives Congres the power. It doesn't mean that Congress must exercise the power.
I fully expect the judges (given past experience with some judges) to go for a self interest fear type of nuanced absurdity.
IOW the second is an individual right and that DC has a strict scrutiny passable interest in protecting DC elitists in disarming the citizens from owning handguns or exercising their individual right. (kind of a time place and manner regulation)
However the citizens are still allowed to own long guns for hunting. (gratuitous sarcasm on last sentence)