There’s a difference in quality.
“Irregardless” is not a word.
“Nukular” is a word, just a wrongly pronounced one.
> Irregardless is not a word.
I used to drive my Dad nuts with my insistence in using Irregardless.
“No such word!” He’d fume.
“Sure there is,” I’d reply. “Irregard is the absence of Regard. Irregard-less means with even Less irregard than the normal amount...”
“No! No! NO!” the hapless English-teacher would fulminate at his smartass son...