We didn’t “lose Ridge” in an election — he resigned in order to head Homeland Security, and his successor declined to run for Governor in the next election.
We didn’t lose Santorum because he’s pro-life — Santorum got triangulated out by a supposedly pro-life son of a famously pro-life former democrat governor. In other words, Santorum held office until the dems ran a pro-lifer against him.
I think your analysis is off in regards to Pennsylvania.
...and I think you are too absorbed in thinking that each campaign is an isolated incident to look at the big picture. The demographics of Pennsylvania are now decisively Dimwit. The fact that Specter is the only Republican holding any power is pretty strong evidence of that. If you look at population and voting trends, you'll see more evidence.
At some point, you should resist the temptation to assume that everyone thinks like you and take an objective look at the facts. It is why we educate ourselves. Your education isn't worth a plug nickel if you do not have the capability to be objective when the circumstances require it.