yes, she can win.
demographic trends are moving against the Rs, especially if they nominate some "litmus test pure" conservative.
Rudy would crush her...
As for the rest of the GOP wannabes ....as they said in the movie "Casino"
"Why take a chance?"
Absolutely. I have no doubt she'll head the ticket with Obama as VP. She absolutely owns the left wing female demographic as well as most radical libs, and Obama will bring in the Black vote and plenty of fringers (including what is known as 'Reagan Democrats' and probably quite a few liberal Pubbies).
Get ready for a very bumpy ride. The Pubbies are like deer caught in the headlights with absolutely no overall strategy I can see to counter the Hillary threat. Our only hope is a moderate like Rudy (I have a problem with that) or a true conservative like Newt (and lots of single-issue 'conservatives' have a problem with that). What with media demonization and a split base, Newt probably can't be elected unless something in the dynamic changes.
The real problem is that there's no such thing as a "conservative vote." We're fractured into several segments that are often at war with each other -- you can see clear evidence of that right here on FR. We got a big taste of that in the past election, with predictable results. If we can't get a unified act together, I'm preparing for at least 8 years of hell on earth.