Your assumption here is that Johnson wouldn't be removed because of incapacitation, leaving SD with in effect, 1 senator. I highly doubt that would stand for very long.
Except for death, the only way a Senator can be removed is resignation or expulsion.
No one can make him resign and the Dems can't be forced to expel him so tough nuggies for S.D.
I believe (haven't found a source) that the leadership remains in place throughout a Senate session even if the majority changes. If that is so then the Dems will expel him after the leadership vote if he is incapacitated. Then SD could replace him.