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To: GourmetDan

You're operating from a junior high understanding of genetics. As I pointed out earlier, coding/noncoding and sense/antisense only have meaning if applied to a particular gene. Both strands are coding for some genes and noncoding for others.


1,024 posted on 09/17/2006 7:04:18 PM PDT by ahayes (My strength is as the strength of ten because my heart is pure.)
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To: ahayes

No, you are merely overstating your case by orders of magnitude.

You are taking the exception that there are some overlapping open reading frames on the anti-sense DNA strand in a number of genes and misapplying it to the problem at hand.

The fact that these O-ORF's exist does not mean that flipping the 5' to 3' orientation to allow head-to-head joining of 2 chromosomes wouldn't destroy the information on the coding strand.

The human chromosome 2 does not have the coding and anti-sense strands flipped as would be required if it were the result of 2 primate chromosomes joining head-to-head.

The problem still exists.

To say that 'both strands are coding for some genes and non-coding for others' may be 'correct' in a technical sense, but it is extremely disingenious and completely inappropriate for solving the problem at hand.

Nice try though.


1,028 posted on 09/17/2006 7:52:42 PM PDT by GourmetDan
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