Since the airport is tower controled 24/7 this is another classic San Diego PSA.
Taking off on the wrong runway it had to be a screw up by the pilot, ground control, and the tower.
Any one of the three could/should have stopped the takeoff.
MSNBC just said there was only one controller in the tower. This is very common at airports the size of LEX. At 6:00am, LEX was likely "TRACAB'd", which means a single controller was working approach/departure, tower, and ground control combined. This is perfectly normal and not a contributing factor. There is almost no air traffic at 6:00am on a Sunday.