The Sox are having to rely on 4 rookie pitchers this year due to the injuries to Foulke and the ineffectiveness of Tavarez and Seanez. Timlin is over the hill and there's no one else that you can reasonably count on other than Papelbon.
I expect that when this series is done that the Sox will be 4.5 out of first and both teams' bullpens will be messed up for several days.
Well I have given up on my Astros