If you think anti-Israel sentiment is high now, not only in the Middle East, but in Europe, Africa, and Asia, let Israel be the first country to use nuclear weapons since 1945 and only the second country to do so in history, and the reaction will be horrendous for both the short and long term interests of Israel. The Islamic Republic of Pakistan, the only islamic country with nuclear weapons, will have some hard decisions to make. And the billion plus muslims around the globe will launch their own jihad against Israeli interests everywhere.
The US will not/not use nuclear weapons against Iran in any preemptive attack.