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How does any theory of the creation of the first lifeforms challenge the mechanisms of ToE?

That depends on the specifics of what you believe ID to believe - just like the flavor of evolution one promotes depends on what version you choose to believe (punt eq, gradualism, etc). Someone who sets for the hypothesis, "in the beginning, God created amino acids," would likely have no trouble with 99% of what evolutionists say (which makes one wonder exactly why evolutionists are as allergic to all IDers as they are...).

On the other hand, the empirical evidence leads me to the conclusion that life on earth came to exist in well defined phyla and that the history of life on earth is one of de-volution/extinction (not evolution). Knowing what I know about biology and science, much of what people say in support of evolution is science fiction based on wishful thinking based on the presupposition that evolution without the intervention of an intelligent designer is already true.